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On The Pen With Dave Knapp
United States
Приєднався 24 жов 2011
🚨 BREAKING NEWS & COMMENTARY: Zepbound / Mounjaro / Ozempic / Wegovy
Get all your GLP-1 news and edutainment here, FIRST!
Don’t miss On The Pen Live on Thursday’s at 9 PM central or my Weekly Dose GLP-1 news Podcast which drops every Tuesday!
DISCLAIMER: No information provided here is to be construed as medical advice. Always consult with a licensed medical provider for medical advice. In no way is this site, it's owners, or its contributors affiliated with Eli Lilly or any other pharmaceutical company.
Get all your GLP-1 news and edutainment here, FIRST!
Don’t miss On The Pen Live on Thursday’s at 9 PM central or my Weekly Dose GLP-1 news Podcast which drops every Tuesday!
DISCLAIMER: No information provided here is to be construed as medical advice. Always consult with a licensed medical provider for medical advice. In no way is this site, it's owners, or its contributors affiliated with Eli Lilly or any other pharmaceutical company.
On The Pen: The Weekly Dose 6.25.24
Send us a Text Message. (www.buzzsprout.com/twilio/text_messages/2302090/open_sms)
Novo Nordisk expansion in the US:
www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=168528
Generic liraglutide
www.onthepen.com/post/teva-launches-first-ever-generic-glp-1-a-game-changer-for-diabetes-and-weight-management
New Wegovy Coupon:
www.wegovy.com/coverage-and-savings/save-on-wegovy.html
New Mounjaro Card (tiktok video)
mounjaro.lilly.com/savings-resources
Tirzepatide (tiktok video):
www.reuters.com/business/healthcare-pharmaceuticals/weight-loss-drug-zepbound-resolves-sleep-apnea-up-52-patients-lilly-says-2024-06-21/
Petrelintide
www.onthepen.com/post/introducing-petrelintide-discover-the-promise-of-amalyn-agonist-medications-for-weight-loss
Gut bacteria:
• Interesting research that shows that type-2 diabetics have more microbiome in their gut that suppresses incretin hormones like GLP-1. This is more evidence that #glp1 (x.com/hashtag/glp1?src=hashtag_click) medications fix what is biologically broken
• www.onthepen.com/post/glp-1-slow-responders-gut-bacteria-may-hold-the-key
DACRA:
ir.vikingtherapeutics.com/2024-06-24-Viking-Therapeutics-Presents-Preclinical-Data-on-Novel-Dual-Amylin-and-Calcitonin-Receptor-Agonists-at-84th-Scientific-Sessions-of-the-American-Diabetes-Association
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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
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ManOnMounjaro
manonthemounjaro
manonthemounjaro
📲 Contact Me: MounjaroMan@gmail.com
📼 PLAYLISTS:
🖊️ ON THE PEN LIVES:
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👀 WATCH MY MOUNJARO JOURNEY IN ORDER:
ua-cam.com/video/aplFxNOv77g/v-deo.html
😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
ua-cam.com/play/PLtOcNl0C8quW-YZuu_DSpt_NS9fVQbMoW.html
🚨📰 ALL THE LATEST MOUNJARO NEWS:
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com.
Novo Nordisk expansion in the US:
www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=168528
Generic liraglutide
www.onthepen.com/post/teva-launches-first-ever-generic-glp-1-a-game-changer-for-diabetes-and-weight-management
New Wegovy Coupon:
www.wegovy.com/coverage-and-savings/save-on-wegovy.html
New Mounjaro Card (tiktok video)
mounjaro.lilly.com/savings-resources
Tirzepatide (tiktok video):
www.reuters.com/business/healthcare-pharmaceuticals/weight-loss-drug-zepbound-resolves-sleep-apnea-up-52-patients-lilly-says-2024-06-21/
Petrelintide
www.onthepen.com/post/introducing-petrelintide-discover-the-promise-of-amalyn-agonist-medications-for-weight-loss
Gut bacteria:
• Interesting research that shows that type-2 diabetics have more microbiome in their gut that suppresses incretin hormones like GLP-1. This is more evidence that #glp1 (x.com/hashtag/glp1?src=hashtag_click) medications fix what is biologically broken
• www.onthepen.com/post/glp-1-slow-responders-gut-bacteria-may-hold-the-key
DACRA:
ir.vikingtherapeutics.com/2024-06-24-Viking-Therapeutics-Presents-Preclinical-Data-on-Novel-Dual-Amylin-and-Calcitonin-Receptor-Agonists-at-84th-Scientific-Sessions-of-the-American-Diabetes-Association
Support the Show. (www.buzzsprout.com/2302090/support)
MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro
BECOME A MEMBER:
ua-cam.com/channels/DocQ-4IhVS3ihy_dW7nSKw.htmljoin
SOCIAL LINKS
www.tiktok.com/@manonthemounjaro
ManOnMounjaro
manonthemounjaro
manonthemounjaro
📲 Contact Me: MounjaroMan@gmail.com
📼 PLAYLISTS:
🖊️ ON THE PEN LIVES:
ua-cam.com/play/PLtOcNl0C8quVdrWruYSrJpTZPF7jjXKfM.html
👀 WATCH MY MOUNJARO JOURNEY IN ORDER:
ua-cam.com/video/aplFxNOv77g/v-deo.html
😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
ua-cam.com/play/PLtOcNl0C8quW-YZuu_DSpt_NS9fVQbMoW.html
🚨📰 ALL THE LATEST MOUNJARO NEWS:
ua-cam.com/play/PLtOcNl0C8quVo0I2YODK-q7cHh4y1r2yB.html
Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com.
Переглядів: 710
Відео
#PEMVIDUTIDE Improves Quality of Weight Loss Over #Zepbound
Переглядів 1,6 тис.4 години тому
Semaglutide (STEP Trials): The primary STEP trials for Semaglutide, particularly STEP 1, 2, 3, and 4, typically lasted for about 68 weeks, which is approximately 16 months. Tirzepatide (SURPASS Trials): The primary SURPASS trials for Tirzepatide, including SURPASS-1, 2, 3, 4, and 5, generally lasted for around 72 weeks, which is approximately 18 months. Pemvidutide (MOMENTUM Trials): At the end...
📣 Introducing: #Petrelintide More Hope for #Zepbound Slow Responders!
Переглядів 1,1 тис.9 годин тому
In the ever-evolving landscape of weight loss medications, Zealand Pharmaceuticals has introduced a promising new player: Petrelintide. The recent 16-week study positions Petrelintide as a potential best-in-class amylin analog, showing impressive weight loss results comparable to well-established GLP-1 receptor agonists. Learn More: www.onthepen.com/post/introducing-petrelintide-discover-the-pr...
On The Pen: The Weekly Dose 6.18.24
Переглядів 1,5 тис.14 годин тому
PBM Reform Form Letter: Link to the Letter: www.onthepen.com/post/pbm-reform-form-letter-for-elected-representatives Express scripts (tiktok video on PBM reform): Link to my video: ua-cam.com/video/l0g6RwViOxc/v-deo.html Michigan (tiktok video) Link (Madison Muller): www.bloomberg.com/news/articles/2024-06-12/michigan-s-largest-insurer-to-drop-weight-loss-drug-coverage Accessibility Link: www.b...
🫃🦠 Why #Mounjaro and #Ozempic Might Not Work for You!
Переглядів 1,2 тис.16 годин тому
www.onthepen.com/post/glp-1-slow-responders-gut-bacteria-may-hold-the-key MY WORK RELIES ON YOUR GENEROSITY, BECOME A MEMBER HERE: ua-cam.com/channels/DocQ-4IhVS3ihy_dW7nSKw.htmljoin Venmo: OnThePen Ca$h App: ManOnMounjaro BECOME A MEMBER HERE: ua-cam.com/channels/DocQ-4IhVS3ihy_dW7nSKw.htmljoin SOCIAL LINKS www.tiktok.com/@manonthemounjaro ManOnMounjaro manonthemounja...
On The Pen: The Weekly Dose 6.18.24
Переглядів 1,1 тис.16 годин тому
Send us a Text Message. (www.buzzsprout.com/twilio/text_messages/2302090/open_sms) PBM Reform Form Letter: • Link to the Letter: www.onthepen.com/post/pbm-reform-form-letter-for-elected-representatives Express scripts (tiktok video on PBM reform): • Link to my video: ua-cam.com/video/l0g6RwViOxc/v-deo.html Michigan (tiktok video) • Link (Madison Muller): www.bloomberg.com/news/articles/2024-06-...
#Wegovy Commercial Got Honest!!
Переглядів 1,2 тис.21 годину тому
The #Wegovy commercial, if it were honest. #semaglutide #novonordisk MY WORK RELIES ON YOUR GENEROSITY, BECOME A MEMBER HERE: ua-cam.com/channels/DocQ-4IhVS3ihy_dW7nSKw.htmljoin Venmo: OnThePen Ca$h App: ManOnMounjaro BECOME A MEMBER HERE: ua-cam.com/channels/DocQ-4IhVS3ihy_dW7nSKw.htmljoin SOCIAL LINKS www.tiktok.com/@manonthemounjaro ManOnMounjaro manonthemounjaro fa...
EXPRESS SCRIPTS: Changing #Zepbound Requirements
Переглядів 1,3 тис.День тому
Advocate By Sharing This Article: www.onthepen.com/post/pbms-overriding-fda-guidelines-for-glp-1-medications-what-can-we-do
#ZEPBOUND AND #MOUNJARO REVOLUTIONIZING LIVER DISEASE TREATMENT?
Переглядів 1,1 тис.День тому
#ZEPBOUND AND #MOUNJARO REVOLUTIONIZING LIVER DISEASE TREATMENT?
WHICH #ZEPBOUND DOSE IS HARDEST TO FIND
Переглядів 1,7 тис.14 днів тому
WHICH #ZEPBOUND DOSE IS HARDEST TO FIND
🫣😱 IS COMPOUND TIRZEPATIDE GOING AWAY?!
Переглядів 2,1 тис.21 день тому
🫣😱 IS COMPOUND TIRZEPATIDE GOING AWAY?!
👀 DISCOVERED: Type 2 Diabetes Reversed?!
Переглядів 56121 день тому
👀 DISCOVERED: Type 2 Diabetes Reversed?!
OTP EPS 68: Ro CEO Zach Reitano Talks GLP-1 Supply Tracker
Переглядів 42921 день тому
OTP EPS 68: Ro CEO Zach Reitano Talks GLP-1 Supply Tracker
📣 ZEPBOUND SUPPLY ANNOUNCEMENT FROM LILLY!!
Переглядів 1,8 тис.28 днів тому
📣 ZEPBOUND SUPPLY ANNOUNCEMENT FROM LILLY!!
On The Pen Live Eps 67: Survodutide Trial Participant Tells All!
Переглядів 771Місяць тому
On The Pen Live Eps 67: Survodutide Trial Participant Tells All!
🔥🔥 RETATRUTIDE AND ORFORGLIPRON NEWS!
Переглядів 2,3 тис.Місяць тому
🔥🔥 RETATRUTIDE AND ORFORGLIPRON NEWS!
🤗 KELLY CLARKSON!!! Is #OnThePen #Mounjaro #Zepbound
Переглядів 1,9 тис.Місяць тому
🤗 KELLY CLARKSON!!! Is #OnThePen #Mounjaro #Zepbound
On The Pen: The Weekly Dose 5.14.24
Переглядів 1,7 тис.Місяць тому
On The Pen: The Weekly Dose 5.14.24
On The Pen: The Weekly Dose 5.14.24
Переглядів 1,1 тис.Місяць тому
On The Pen: The Weekly Dose 5.14.24
I love how knowledgable you are on all of this! Keep up the incredible content.
Congratulations, Dave! I'm so happy for you!
Most helpful!
Woohoo - I’ve asked for a sleep study after 63 # lost. We will see.
Is there a blood test yet for dppt4?
I wouldn’t count on Viking. I don’t think they have the capability of manufacturing nor the financial backing to do it. They had to raise money to do the trail. They are a group of board members pushing a PR campaign to pump the stock price and try to get an investing company to buy them out.
I think this is fairly accurate
@@ManOnTheMounjaro also, there are so many good new variants of glp-1’s in the works, some better then others and out doing each other in initial trails. But when you look deeper, they are 3-5 years away. I hope by then, I won’t need them. But I think Retatrutide will be my go to for longevity(like a shot every month for maintenance and overall metabolic health maintenance.
I’ve always thought this. 🤔
😂
The absolute very best cure for obesity is totally free . . . It’s called Ketogenic or carnivore diets!
Thanks!
Thanks so much!
Dave. Why couldn’t Viking release their injectable in vials? Is this different from what you have been advocating for from Lilly and Novo?
Based on their last earnings call, the CEO of Viking believed that they needed a pen to compete with the existing products. It is a mystery why none of these companies want to do vials.
They should!!
If I had to guess, I’d say it’s ‘cuz they won’t do vials unless EVERYONE ELSE is doing vials. 🧪 And I think that’s Lilly and Novo’s unspoken stance in the US market too. ‘Cuz the user experience on vials isn’t quite as good as it is on a pen. At least until you get used to it. So the pen’s *an advantage,* in a way. So no one wants to risk losing eventual/future market share. They won’t do it ‘til everyone else does it, and no one wants to go first in the super-lucrative US market. 💰 Which is why I think Lilly’s KwikPen (multi-use pen) is the way to go… helps alleviate pen-caused production shortages, while still providing a good user experience. 🌟 #RelaseTheKwikPen
So much good news! The future is really bright. I had no idea that there would be this much news out of the American Diabetes Association Scientific Session in Orlando. I regret not attending in person.
Very exciting news! 👏🏾
Thank you Dave. I love my Tirzepatide! ❤
Me too!
I think it really depends on the person. Weight loss is weight loss all these drugs make you eat less. That’s it. I think the muscle loss is coincidental depending on the person.
Hi Dave, Love your updates and short videos. Thanks so much!! 👏👏👏
Glad you like them!
You’re so helpful 😍🙏
Glad you think so!
*Sidenote:* Not 100% sure, but I think Novo changed the Wegovy manufacturer’s coupon fairly recently. IIRC, it used to be 500 off the list price (so, $849 for the out-of-pocketers), but now you pay 650 OOP. But, you do have to have commercial insurance (which doesn’t cover it), not sure if that was a requirement before. 🤔 If this really is what’s happened, then still not as good a deal as Zepbound ($550 OOP w/coupon), but you could consider it a PRICE CUT by Novo. Wotta concept. 😯
Checked it- yeah, looks like they quietly changed that part of the saving card effective May 30th. So, like three weeks ago. ☑️
Very cool. Was a bit worried this would slip to later this year. 👍 But as you’ve reported and I’ve said, with generics, there’s often a lag between release and the price dropping a lot. IIRC, that’s usually about 6-12 months. Still really good news. ✨ And I guess the next GLP-1 to go to generic is Trulicity, with the patents expiring in 2027.
Do you ever see a world where Lilly might sell the rights to Trulicity?
That’s a really interesting idea. Apparently Lilly *did* already sell the rights to Trulicity in India to a local company there (Cipla). To do the same in the US would offer some big advantages in freeing up production capacity for Lilly’s newer GLP-1s. I mean heck, Trulicity uses the *exact same pen* as Mounjaro and Zepbound. 💡 I once had the (extreme?) idea of Lilly licensing their Tirzepatide meds to other Big Pharma players who had spare production capacity. Doesn’t seem like they’ll ever do THAT, but selling the rights to Trulicity, if the price/deal was right, seems more doable and strategically really smart. (Maybe they should put y’all in the C-suite at Lilly, Dave. 😎)
When the price of the generic lowers and we can get it for weight loss, what percentage of patients will use this daily as opposed to Zep/MJ and Wegovy/Ozempic? I'm wondering when we accept 'basic and cheap' over 'best and expensive'.
@Sue Depends on how much cheaper the generic gets, I’d think. If it’s not WAY cheaper than Tirzepatide or Semaglutide, it’s a pretty heavy lift. ‘Half as good WL results and you stick yourself EVERY day’ ain’t exactly sexy. Zep’s 550 OOP, and Weg’s 650 OOP. So, maybe if it’s priced at *half* that, it could get 10-15 percent of the WL market, absolute max? Of course, compounded semaglutide would be both better and about the same price. But many ppl don’t even know about compounds, or they refuse to try them and favor name-brands.
@cloakster Any guesses on whether Victoza could be used for maintenance after taking tirzepatide?
Dave always has his finger on the pulse ❤
Omg
This is huge. I know you said this was daily, do you think that will affect how much they can actually get into patient's hands? Are we looking at an Ozempic/Mounjaro shortage Times Seven?!? 😮
Yeah, it’s a daily injectable, but Victoza and Saxenda use a multi-dose pen. ☑️ (So why the heck MJ/Zep still DOESN’T is beyond me.)
wish i knew this before,kinda late.
Was it because of the med itself or because they lost weight
Good monday afternoon Dave
How do pharmacies have the ability to set guidelines for medical treatment?
This was true for me only the 1st few months! All the cravings are back 🫣
So frustrating my friend! I feel your pain!
Positivity is contagious. Spread it! 🌈
Nice vid on an important topic, Dave. 🌟 On Bimagrumab, I’m a little less stoked on that one than I used to be. ‘Cuz apparently, - It’s expensive. - The side-effects profile ain’t great. - Requires an IV infusion. - Da added muscle doesn’t improve strength Maybe Lilly’s working some mojo in the trials to improve some of those things, but still, may not be quite the upgrade we were hoping for. 😐 On Pemvidutide: Those results on quality of weight-loss are sure great (IIRC 30-40 percent of WL being lean-mass loss is pretty typical for ‘natural’ WL, so holding it to 21 percent is amazing)… BUT, I’m not sure that’s attributable to the glucagon component. 🤔 From what I’ve read, glucagon actually has a *catabolic* effect, aka it can break down muscle and the associated amino acids, not build them. If that’s the case then Pemvidutide is either doing something *else* to preserve muscle mass, or those results are slightly suss (‘gamed’/atypical patient population?). In fact, one of my worries is that Reta, Survodutide, etc (all the glucagon meds) will be a bit *worse* at preserving lean mass than current-gen meds. Very much hope that’s NOT the case. 🙏
Then maybe we need to look at the design of the trials… My sense is that Lilly wouldn’t have acquired Versanis if they thought it could be a bust… Though it could have simply been a chess move to grab it before Novo did, since Bimab was already in trials with Sema. I think it’s a wait and see on the glucagon agonists. Those meds seem to be doing so much metabolically, perhaps the natural inclination to “move more” with increase energy offsets your hypothesis… Either way…. I am here for it, and I’m glad there are others that need out on this stuff as much (more) than I do!!!
Would definitely hope the Phase 3 readouts on the glucagon meds show us what’s what on their lean-mass preservation. 🤞 (And as a fatty-liver guy, I WANT to be on a glucagon med.)
Thx Dave for spotlighting Pemvidutide and Altimmune!!🎉❤
This is potentially amazing. 😯🌟
Exciting news
Awesome news
It’s possible to not lose if we put in the work. Ive lost 152lbs in 20 mos on Mounjaro. Pcos, hypothyroidism, insulin resistance no diabetes. Over 45. Had Dexa scan done muscle mass is in perfect range. Ive gained 8lbs of muscle the past 10 mos while in a calorie deficit and my BMR is higher now vs 70lbs heavier 😳😳. I was shook. In case anyone cares lol I strength train 2 days a week full body 1 hour each session with adequate rest in between, which is recommended for us older gals lol. I also walk 5-6 miles a day. Thats all I do for exercise. Strength training is so important on any weight loss journey, wish more would get on board. I started weights 3 months into my Glp journey. I average 1300-1400 calories a day and 100g of protein. Still losing eating the same calories I was eating 70lbs heavier because Ive put on muscle.
Thanks for the current information.
Thank you Ray!
Thanks for great information!
My pleasure! Appreciate you watching!!
Hi Dave! Just want to say I appreciate you so much. I just completed my first full month on compound Tirzepatide and couldn’t be happier l with it. I am fascinated with GLPs now, because of what they are doing for me, and I’m just so thankful I found you. Thank you for all the great information you share with us!
I’m so glad Lori! Glad that you are doing so well, and glad you enjoy the content.
I just discovered this podcast and youtube channel. This is the best content I've found on GLP1s. Thanks for all the work you put into this!
Walter 😂
I stopped using my cpap after being on this drug
So awesome!
Love good news! All the slow or non-responders may be lucky in the long run by losing their weight with the next generation of drugs.
Congrats on reporting this news within literally 15 minutes of the presentation at the American Diabetes Association Scientific Conference in Orlando
😉
And others who copy his work will have the videos up tonight, tomorrow or a couple days from now 😅😅
@shewygirl haha it tickles me that other people notice it too 😂
@@ManOnTheMounjaro facts and Im like…. UM YUP THEY SAW DAVES VIDEO. We know who the og glp news guy is and the source and what you put into this and appreciate it greatly 👏🏼👏🏼🙌🏼🙌🏼🫡🫡
@shewygirl I appreciate it! (And Clark who provides a ton of the news lately)